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Ifactor california10/24/2022 ![]() It facilitates ingrowth of bone by promoting the migration of mesenchymal stem cells and other progenitor cells from surrounding tissue. This induces cell proliferation, differentiation and subsequent osteogenesis. Attachment of P-15 to osteogenic cells initiates a cascade of intracellular signalling that triggers the synthesis of extracellular matrix and growth factors. P-15 amino acid is similar to the one found in type 1 collagen of bone. The biologically active component is a synthetic 15 amino acid residue which when combined with the anorganic matrix provides a scaffold for cell invasion, binding and osteogenesis. The anorganic bone matrix is composed of calcium phosphate which provides osteoconductive properties of cell invasion and migration. I-Factor TM is a composite made of anorganic bone matrix and bioactive P-15 peptide. There is no published literature regarding its complication profile in spinal surgery for children. ![]() The few published studies of i-Factor were on adults who had spinal surgery. There is a paucity of literature evidence to support its efficacy and safety. ![]() ![]() Peptide enhanced composite graft was granted permission in 2008 for use in Europe. However, it is associated with complications such as donor site morbidity, increased surgical time and limited supply. Iliac crest bone grafting remains gold standard for fusion procedures. Spinal fusion is a crucial step in correction of deformity to prevent failure of metalware and progression of deformity. ![]()
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